Following the recognition of its role in sensory-motor coordination and learning, the\r\ncerebellum has been involved in cognitive, emotional, and even personality domains.\r\nThis study investigated the relationships between cerebellar macro- and micro-structural\r\nvariations and temperamental traits measured by Temperament and Character Inventory\r\n(TCI). High resolution T1-weighted, and Diffusion Tensor Images of 100 healthy subjects\r\naged 18ââ?¬â??59 years were acquired by 3 Tesla Magnetic Resonance scanner. In multiple\r\nregression analyses, cerebellar Gray Matter (GM) or White Matter (WM) volumes, GM\r\nMean Diffusivity (MD), and WM Fractional Anisotropy (FA) were used as dependent\r\nvariables, TCI scores as regressors, gender, age, and education years as covariates.\r\nNovelty Seeking scores were associated positively with the cerebellar GM volumes and\r\nFA, and negatively with MD. No significant association between Harm Avoidance, Reward\r\nDependence or Persistence scores and cerebellar structural measures was found. The\r\npresent data put toward a cerebellar involvement in the management of novelty.
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